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Endocrine Abstracts

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ea0050p316 | Obesity and Metabolism | SFEBES2017

Low vitamin B12 in pregnancy is associated with adipose derived circulating miRNAs targeting PPARγ and insulin resistance

Adaikalakoteswari Antonysunil , Vatish Manu , Alam Mohammad , Ott Sascha , Kumar Sudhesh , Saravanan Ponnusamy

Background: Low vitamin B12 (B12) during pregnancy is associated with higher maternal obesity, insulin resistance (IR) and gestational diabetes (GDM). However, it is not clear whether these are causally related.Objective: B12 is a key co-factor of the DNA methylation cycle (1-carbon metabolism). We hypothesize that B12 plays a role in epigenetic regulation by altering circulating miRNAs (miRs) during adipocyte differentiation...
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ea0050p316 | Obesity and Metabolism | SFEBES2017

Low vitamin B12 in pregnancy is associated with adipose derived circulating miRNAs targeting PPARγ and insulin resistance

Adaikalakoteswari Antonysunil , Vatish Manu , Alam Mohammad , Ott Sascha , Kumar Sudhesh , Saravanan Ponnusamy

Background: Low vitamin B12 (B12) during pregnancy is associated with higher maternal obesity, insulin resistance (IR) and gestational diabetes (GDM). However, it is not clear whether these are causally related.Objective: B12 is a key co-factor of the DNA methylation cycle (1-carbon metabolism). We hypothesize that B12 plays a role in epigenetic regulation by altering circulating miRNAs (miRs) during adipocyte differentiation...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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